Manufacture of disinfectants



Patented July 2 8, 1931 UNITED STATES PATENT OFFICE FRIEDRICH RASCHIG, or L UnwIGsHArEN-eN-TnE-RHINE, GERMANY, ASSIGNOR 'ro THE FIRM DR. F. ansonre, or LUD'WIGSHAFEN-ON-THE-RHINE,GERMANY MANUFACTURE or msmnncrnurs No Drawing.

My invention relates to the manufacture of disinfectants and more particularly to a water-soluble disinfectant of which a monovalent phenolic body is cut.

Antiseptic substances. of great potency which are to be used for disinfecting pur poses, must be soluble in water, for otherwise they could not be applied in the majorl l0 ity of cases where they would be of use.

It is known that certain antiseptic substances,'which are not soluble in water, may be rendered soluble in water by means of a .soap solution, whilst many other substances of antiseptic be rendered soluble in water in thisway to a, satisfactory degree except by .or upon the addition of asuitable agent. Thus thymol requires anaddition such as formaldehyde in order to become soluble ina soap solution, chlorophenols cannot at whereas the several all be rendered soluble in water by means of soap, except a certain chloro-meta-cresol.

My object is to produce a water soluble disinfectant from chloro-thymol. Judging from experience and knowledge hitherto prevailing it could not be assumed that chloro-thymol which has .a higher molecular weight and is still by far less soluble in Water than thymol, might be rendered soluble in water in a practically useful degree by means of a mere soap addition. Contrary to expectation, however, I have found that chlorothymol made by slowly adding or dripping sulphuryl chloride into thymol, and melting at 62 to 64 C.,-may be rendered soluble in water by the addition of a reasonable proportion of soap, although the said chlorothymol without the addition of the stated solvent element is of a very slight solubility in water not exceeding 0,03 per cent. It is to be noted that the antise tic or bactericidal potency of ch1oro-thymo is so enormous that the simple aqueous solution thereof containing 0,03 per cent of chlorothymol only, will give satisfaction in some cases or for certain purposes.- Even if the vprodi 'ous antise tic power of chloro-thy- -mol s ould be re uced a little by the addition or presence of, larger amounts of soap the main constituor disinfecting nature cannot- Ap lication filed February 17, 1927. Serial No. 169,139.

than required in connection with the com Inonly used cresol, still the antiseptic efl ect of the former vwill be so high as toexcel by far that of the higher phenols hitherto employed for similar purposes.

I shall now proceed to describe the manner in which I manufacture the new disinfectant according to my invention. My invention viewed fom its broadest aspect resides in the production and obtention of water-soluble chloro-thymohbut includes also a particular or preferred manner ofimanufacturing the same. Broadly I mix chloro-thymol with a suitable soap and a suitable alcohol. A mixture of 1 part by weight of chloro-thymol, 3 parts by weight of potassium-soap, and 1 part by weight of ethylic alcohol Will give satisfactory results in all cases. 'Preii'erably, however, I combine or unitebothl the manufacture of the soap and the oper tion of mixing the same with the other-constituents so as to form a compound process. The structural formula of chloro-thymol isopropyl-6 chlorobenzol.

With this weight of castor oil or a similar or equivalent oil ora mixture of the same with 5 parts by and10 parts by weight of ethylie alcohol, and

I beat the mixture for a length of time sulficient torender the same soluble in water.

Upon subsequent cooling the mixture will,

chloro-thymol which is preferable'for certain purposes owing to the easier. dosing readiness thereof.

' The antiseptic or disinfecting power of a chioro-thymol solution of the described kind 1s creshl solutions of a still higher concentration. For general use one art of thesaid 10 per cent solution may be iluted with 200 parts of water in orderto obtain a disinfect is 1 methyl-3 hydroxy-e object in view I mix 25 parts by far. superior to that of cresol orchloro for the purpose" iweight of caustic potash or potassmm hy-' dra te, 10 parts by weight of 'chloro-thymol' some cases, p or water tonot always required and emulsions in wh I found that emulsions,

' 50 parts,

will be of sufficient strength ing liquor which application for disinfecting in most cases of purposes.

Afurther advantage'of 'my improved disinfectant resides in the fact that the slight smell thereof is not unpleasant and-not at all so offensive as that of phenol or chloro-cresol. The 10 per cent solution above mentioned is, chemically speaking, a chloro-thymol soap be diluted with any still will remain absolutely clear and limpid. It goes without saying that the comparatively higlr'proportion of soap therein is necessary solely for the purose of complying with the requirement 0 limpid solutions. I however, clear solutions arfi quantity of water and obtaining clear In practice,

the chloro-thymol is dispersed and evenly suspended in the form of extremely minute particles and which, therefore, are not limpid, nevertheless answer sometimes the purposes for which they are to be employed. Obviously in case of manufacturing a commercial solution for the purpose an amount of soap may be used which ,is considerably less than the proportion, required for the pros duction of the solution herein before scribed. Thus in the above described 10 per cent ChlOlQrthY-IHOI soap solution the proportion of chlorohymol while a commercial 50 per cent'chloro-thymol soap solution, for exemplification, may be manufactured in an analogous manner to contain soap in the proportion of'Q to 1, that is one part of chloro'thymol to half a part of soap.

In preparing an emulsion tion water is to amount required or desired. It '18 to be noted, however, that an emulsion made in this way will not keep for 'a greater length of time for the reason that the chloro-thymol soon separates and form.

Now after much study and research I have keep well for a long period of time may be obtained by employlng, or similar oils as above'described, a mixture that my invention,

to soap is like 1 to 3,:

dep osits in crystalline which are stable and thereof are fully liquefied to form a uniform or homogeneous liquid. Water is or may be added to the latter as required or desired and the alcohol may be replaced, partially or wholly, by any other suitable substances which will act to reduce the congealing or solidifying tendency of the chloro-thymol, such. as cyclohexanon, camphora and the like. I have not attempted to explain all of the minute details of the processor-operations of manufacturing my improved disinfectant,

for it will be understood by those to whom this specification is addressed, that all of the operations required for the purpose, will necessarily have to be carried out in accordance with the known rules and tenets of modern chemistry. It, therefore, will be evident,

while still being adhered to in its main essentials, may be varied and adapted in many ways, according to the requirements desired, or most suitable under different circumstances.

What I claim is 1. A disinfectant composition of high concentration, comprising chloro-thymol and sea '2. A disinfectant composition of high concentration forming stable emulsions with water, comprising .chloro-thymol and a resinous soap.

3. A disinfectantcomposition, comprising chloro-thymol, a resinous soap and oleic acid.

In testimony whereof I have affixed my signature. I I

FRIEDRICH RASGHIG.

from the last mentioned or 50 percent chloro-thymol solu-- be addedto the latter to the in lieu of castor oil of a suitable resin and oleic acid or the like in preparing the initial or commercial 50 per cent chloro-thymol solution above described. By way of example I mix -20 parts] (by weight) ofcolophony or any similar or equivalent resinous substance, 2 parts by weight of oleicacid, 20 parts by weight of alcohol,

(byweight of chloro-thym'ol, 8 pegs (by weight) of caustic soda of 40 and I heatth'e' mixture until the ingredients 

